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BCL2L1/Bcl-2-like protein 1


Recombinant Human BCL2L1/Bcl-2-like protein 1 (C104)


产品说明(Description)

Recombinant Human B Cell Lymphoma/Leukemia x Long Form is produced by our E.coli expression system and the target gene encoding Met1-Arg212 is expressed with a 6His tag at the C-terminus. 

Accession #: Q07817

Known as: Bcl-2-Like Protein 1; Bcl2-L-1; Apoptosis Regulator Bcl-X; BCL2L1; BCL2L; BCLX


制剂(Formulation)

Supplied as a 0.2 μm filtered solution of 20mM HEPES, 50mM KCl, 20% Glycerol, pH 7.5.


质量控制(Quality Control) 

Purity:            Greater than 95% as determined by reducing SDS-PAGE.    

Endotoxin:    Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.


复溶(Reconstitution)

   


保存(Storage)

Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.   


背景(Background)

Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.


电泳(SDS-PAGE)


FOR RESEARCH USE ONLY

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