产品Product

肾脏疾病

Human KIM-1 (诊断原料,肾脏疾病)

Recombinant Human KIM-1 


Catalog # DRA03        Derived From: Human Cells   


Description:

Recombinant Human KIM-1 is produced by Mammalian expression system and the target gene encoding Ser21-Gly290 is expressed with a 6His tag at the C-terminus. 

Accession:  F1CME6

Names(Known as):HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, Hepatitis A virus cellular receptor 1


Quality Control:

Mol Mass:  29.8kDa            AP Mol Mass:  80-120kDa, reducing conditions

Purity:  Greater than 95% as determined by reducing SDS-PAGE.


Formulation:

Supplied as a 0.2 μm filtered solution of PBS,pH7.4,5% Trehalose.


Shipping:

The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.


Storage:

Reconstituted protein solution should be stored at ≤ -20°C.


Purification: 
Affinity purification chromatography.


Immunoreactivity: 
N.A.


Application:
Immunogen, calibrator or standard.


Background:

Kidney injury molecule-1 (KIM-1) (also known as TIM-1 and HAVCR) is a type 1 transmembrane glycoprotein found on activated CD4+ T cells, especially Th2 cells, and dedifferentiated proximal tubule epithelial cells. In humans, KIM-1 levels are very low or undetectable in normal samples, but following drug toxicity or ischemic damage to the kidney, the 85 kD, mucin-rich extracellular region of this molecule is shed and detected at elevated levels in urine, serum, and plasma. Therefore, KIM-1 is a suitable renal biomarker capable of early detection and progressive monitoring of acute kidney injury beyond traditional injury markers such as serum creatinine (SCr) and blood urea nitrogen (BUN) which lack specificity and sensitivity. KIM-1 has also been implicated in the development of atopic airway disease (asthma) and Th2-biased autoimmune responses.


FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY



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